Science 2016-07-29.pdf

424 29 JULY 2016 VOL 353 ISSUE 6298sciencemag.org SCIENCE29 JULY 2016 VOLUME 353 ISSUE 6298CONTENTSPHOTO:(TOP)ROLAND SEITRE/MINDEN PICTURES461Two-dimensional frontiersNEWSIN BRIEF428 News at a glanceIN DEPTH 432 OBSTACLES LOOM ALONG PATH TO THE END OF AIDSInternational meeting highlights clash between ambitious goals and wobbly funding By J.Cohen433 CHIMPANZEE SANCTUARIES OPEN DOOR TO MORE RESEARCHCollaboration aims to beef up science at retirement centers By D.Grimm434 RETHINKING THE NORTH AMERICAN WOLFGenome sequencing suggests two endangered wolf species are coyote hybrids By V.Morell SCIENCE ADVANCES RESEARCH ARTICLE BY B.M.VONHOLDT ET AL.436 AFTER FAILED COUP,TURKEYS ACADEMICS FEEL REGIMES WRATH Thousands of researchers and university of cials fi red,suspended,or told to return home immediately By J.BohannonINSIGHTSPERSPECTIVES 442 PARASITIC PLANTSA CURE FOR WHAT AILS THEEA parasitic plant is perceived by its host plant in a similar manner to microbes By V.Ntoukakis and S.Gimenez-Ibanez REPORT P.478444 ON THE RECORD WITH E.COLI DNADNA can be engineered for cells to record events in real time By O.Borkowski et al.RESEARCH ARTICLES PP.462&463445 THE SMOKING GUN FOR ATLANTICCIRCULATION CHANGESDeep-sea sediments record changes in ocean circulation during the last glacial age By A.Schmittner REPORT P.470446 PLANT EXTINCTIONS TAKE TIMEMany plant species may already be functionally extinct By Q.CronkPOLICY FORUM 448 COUNTERING IMPRECISION IN PRECISION MEDICINEBetter coordination is needed to study complex interventions By S.P.Hey and A.S.KesselheimBOOKS ET AL.450 I CONTAIN MULTITUDESBy E.Yong,reviewed by S.Perkins451 HISTORY WITHINBy M.Sommer,reviewed by M.MeloniLETTERS 452 CLARIFYING SAMPLESIN ZIKA ANALYSESBy J.R.M.de Oliveira and D.A.P.Moura452 ANIMAL-BASEDANTIBODIES:OBSOLETEBy A.C.Gray et al.453 THE LINE BETWEENSCIENCE AND POLITICSBy M.Weintraub453 TECHNICAL COMMENT ABSTRACTS437 UNCERTAINTY REIGNSIN BREXIT BRITAINAs U.K.universities counsel their E.U.staf ,researchers see fi rst signs of fallout By E.StokstadFEATURE 438 FORBIDDEN PLANETSHow the zoo of exoplanets has turned planet formation theory upside down By D.Clery4344384TPublished by AAAS on July 28,2016http:/science.sciencemag.org/Downloaded from 506HIV assembly29 JULY 2016 VOL 353 ISSUE 6298 425SCIENCE sciencemag.org503A Zika drug targetScience Staf .426News&Notes.455New Products.509Science Careers.510DEPARTMENTS427 EDITORIAL Intentional equityBy France A.Crdova514 WORKING LIFEGrowth from failureBy Tenaya K.ValleryON THE COVERHypogymnia imshaugii,a macrolichen common in northwestern North America.Lichens were previously thought to contain two parts:an ascomycetous fungus and a photosynthetic alga.Spribille et al.show that a third elementa basidiomycete yeastis part of the lichen cortex in the largest group of macrolichens.See page 488.Photo:Timothy B.Wheeler/SCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing of ces.Copyright 2016 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership and subscription(51 issues):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1522;Foreign postage extra:Mexico,Caribbean(surface mail)$55;other countries(air assist delivery)$89.First class,airmail,student,and emeritus rates on request.Canadian rates with GST available upon request,GST#1254 88122.Publications Mail Agreement Number 1069624.Printed in the U.S.A.Change of address:Allow 4 weeks,giving old and new addresses and 8-digit account number.Postmaster:Send change of address to AAAS,P.O.Box 96178,Washington,DC 200906178.Single-copy sales:$15.00 current issue,$20.00 back issue prepaid includes surface postage;bulk rates on request.Authorization to photocopy material for internal or personal use under circumstances not falling within the fair use provisions of the Copyright Act is granted by AAAS to libraries and other users registered with the Copyright Clearance Center(CCC)Transactional Reporting Service,provided that$35.00 per article is paid directly to CCC,222 Rosewood Drive,Danvers,MA 01923.The identif cation code for Science is 0036-8075.Science is indexed in the Readers Guide to Periodical Literature and in several specialized indexes.442&4785ARESEARCHIN BRIEF 458 From Science and other journalsREVIEW461 APPLIED PHYSICS2D materials and van der Waals heterostructures K.S.Novoselov et al.REVIEW SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aac9439RESEARCH ARTICLES 462 CELL LINEAGE TRACINGWhole-organism lineage tracing by combinatorial and cumulative genome editing A.McKenna et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aaf7907 PERSPECTIVE P.444463 SYNTHETIC BIOLOGYMolecular recordings