Science 2016-03-11.pdf

sciencemag.org SCIENCECONTENTS1154&1196Soda bottles for dinner11 MARCH 2016 VOLUME 351 ISSUE 62781112 11 MARCH 2016 VOL 351 ISSUE 6278CONTENTSNEWSIN BRIEF1120 News at a glanceIN DEPTH 1122 MARS ORBITER TO SNIFF FOR METHANEMission aims to settle whether gas existsand whether it could hint at life By E.Hand1123 EVIDENCE GROWS FOR ZIKA VIRUSAS PREGNANCY DANGERLab experiments and new clinical data suggest that fast-spreading virus attacks developing brain By G.Vogel1124 IN SEARCH OF SPACETIME MEGAWAVESTiming in celestial radio beacons could reveal gravitational tsunamis By D.Clery1126 WHY HIGH GOOD CHOLESTEROLCAN BE BAD NEWSA faulty transport system sometimes causes high HDL By J.Couzin-Frankel RESEARCH ARTICLE P.11661127 PLANS FOR NEW RESEARCH HUB GET CRITICAL RECEPTIONScientists welcome new money but worry about lack of transparency By L.MargottiniINSIGHTSPERSPECTIVES 1148 ENDING HIDE AND SEEK AT SEANew technologies could revolutionize ocean observation By D.J.McCauley et al.1150 THE INVISIBLE DIMENSION OF FUNGAL DIVERSITYCan microbial taxa be defi ned from environmental molecular sequences?By D.Hibbett1152 THE TIME IS RIGHT FORMULTIPHOTON ENTANGLED STATESA chip-based microresonator enables time-bin entanglement By A.C.Peacock and M.J.Steel REPORT P.11761153 UNRAVELING A PATHWAY TO AUTISMA signaling pathway that controls protein synthesis may be a target for autism therapeutics By J.P.H.Burbach REPORT P.1199;RESEARCH ARTICLE BY F.YI ET AL.10.1126/science.aaf26691154 FEEDING ON PLASTICA bacterium completely degrades poly(ethylene terephthalate)By U.T.Bornscheuer REPORT P.1196SPECIAL SECTIONForensicsNEWS 1128 Evidence on trialBy M.Enserink1130 Sizing up the evidenceBy K.Servick1133 When DNA is lying By D.Starr1134 How hair can reveal a history By H.Armitage and N.Rogers1136 A trail of microbesBy K.Kupferschmidt1138 Who dropped the bomb?By R.Stone1140 Whose voice is that?By N.Rogers1141 Clues from the ashesBy L.Wade1143 The microbial death clock By K.Kupferschmidt1144 The Bitcoin bustsBy J.BohannonSEE ALSO PODCASTON THE COVERBullets fi red from the same pistol by the Prince Georges County Police Department,in Maryland,show similar but not identical markingsan example of the ambiguity that plagues much crime-scene evidence.The bullets were fi red as part of a research ef ort to bring greater rigor to forensic analysis,conducted by the National Institute of Standards and Technology.See page 1128.For more on the process behind the cover image,see http:/scim.ag/1LPKy4C.Photo:Matthew Rakola1123Published by AAASon March 10,2016Downloaded from on March 10,2016Downloaded from 11 MARCH 2016 VOL 351 ISSUE 6278 1113SCIENCE sciencemag.org1208&1214Metabolic rewiring in cancer cellsIMAGE:(BOTTOM RIGHT)PETER ALLEN/UCSBRESEARCHIN BRIEF 1162 From Science and other journalsRESEARCH ARTICLES 1165 BACTERIAL PILIArchitecture of the type IVa pilus machine Y.-W.Chang et al.RESEARCH ARTICLE SUMMARY;FOR FULL TEXT:dx.doi.org/10.1126/science.aad20011166 HEART DISEASERare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease P.Zanoni et al.NEWS STORY P.11261171 CHEMICAL PHYSICSWavelike charge density fl uctuations and van der Waals interactions at the nanoscale A.Ambrosetti et al.REPORTS 1176 QUANTUM OPTICSGeneration of multiphoton entangled quantum states by means of integrated frequency combs C.Reimer et al.PERSPECTIVE P.11521180 SPIN MODELSSimple universal models capture all classical spin physics G.De las Cuevas and T.S.Cubitt PERSPECTIVE P.11561184 TOPOLOGICAL MATTERQuasiparticle interference of the Fermi arcs and surface-bulk connectivity of a Weyl semimetal H.Inoue et al.1188 ZEOLITESAccelerated crystallization of zeolites via hydroxyl free radicals G.Feng et al.1192 FUNGAL ENZYMESEarly-branching gut fungi possess a large,comprehensive array of biomass-degrading enzymes K.V.Solomon et al.1196 BIODEGRADATIONA bacterium that degrades and assimilates poly(ethylene terephthalate)S.Yoshida et al.PERSPECTIVE P.11541199 NEURODEVELOPMENTCLK2 inhibition ameliorates autistic features associated with SHANK3 defi ciency M.Bidinosti et al.PERSPECTIVE P.1153;RESEARCH ARTICLE BY F.YI ET AL.10.1126/science.aaf26691204 CANCER BIOLOGYSchedule-dependent interaction between anticancer treatments S.Chen et al.SCIENCE(ISSN 0036-8075)is published weekly on Friday,except the last week in December,by the American Association for the Advancement of Science,1200 New York Avenue,NW,Washington,DC 20005.Periodicals mail postage(publication No.484460)paid at Washington,DC,and additional mailing of ces.Copyright 2016 by the American Association for the Advancement of Science.The title SCIENCE is a registered trademark of the AAAS.Domestic individual membership and subscription(51 issues):$165($74 allocated to subscription).Domestic institutional subscription(51 issues):$1522;Foreign postage extra:Mexico,Caribbean(surface mail)$55;other countries(air assist delivery)$89.First class,airmail,student,and emeritus rates on