临床医学研究与实践2023年3月第8卷第7期ResearchprogressofchemotherapyrelatedbonemarrowsuppressioninbreastcancerPENGQingying1,ZHANGYuanqi2*(1.GuangdongMedicalUniversity,Zhanjiang524000;2.AffiliatedHospitalofGuangdongMedicalUniversity,Zhanjiang524001,China)ABSTRACT:Breastcanceristhemostcommoncanceramongwomenworldwide.Althoughthetargetedtherapyofbreastcancerisbecomingmoreandmorepopular,butchemotherapyisstillanimportantmeasuretotreatthedisease,itcankilltumorcellsandpromotetumorvolumereduction,reducetherecurrencerateofbreastcancer,improvethequalityoflifeofpatients,andisexpectedtoachievethegoalof"cure".However,chemotherapyrelatedadversereactionsarealsoaccompanied,amongthem,chemotherapyinducedbonemarrowsuppressionisakeyfactoraffectingthecourseanddoseofchemotherapy.Thereareindividualdifferencesinthedegreeanddurationofbonemarrowsuppressioninbreastcancerpatients,andthepreventionortreatmentmeasuresforbonemarrowsuppressionarecarriedoutaftertheendofchemotherapy,whichgreatlyincreasesthedifficultyofpatientmanagementandtheriskofinfection,ifappropriateindicatorscanbefoundtopredictpatientswithbonemarrowsuppressionandearlyinterventioncanbegiven,theprognosisofpatientswillbeimproved.Thisreviewattemptstostudythemechanismandriskfactorsofbonemarrowsuppression,soastoprovideideasfortheprevention,monitoringandmanagementofchemotherapyrelatedbonemarrowsuppressioninthefuture.KEYWORDS:breastcancer;chemotherapy;bonemarrowsuppression乳腺癌化疗相关骨髓抑制的研究进展彭庆颖1，张远起2*（1.广东医科大学，广东湛江，524000；2.广东医科大学附属医院，广东湛江，524001）摘要：乳腺癌是全球女性最常见的癌症。尽管乳腺癌的靶向治疗日益普及，但化疗仍是治疗该病的重要措施，可起到杀灭肿瘤细胞及促进肿瘤体积缩小的作用，降低乳腺癌的复发率，改善患者的生存质量，有望达到“治愈”的目的。然而化疗相关不良反应也如影随行，其中，化疗诱导的骨髓抑制是影响化疗疗程及剂量的关键因素。乳腺癌患者的骨髓抑制程度以及持续时间存在个体差异，针对骨髓抑制的预防或治疗措施均在化疗结束后进行，这极大增加了患者的管理难度及感染风险，若能探索出合适的指标...
