去乙酰毛花苷注射液联合米力...合并心衰的疗效及安全性分析_李爽.pdf

96Clinical Research,Mar.2023,Vol.31 No.03作者简介：李爽，女，主治医师，硕士研究生。研究方向：重症肺炎、腺病毒肺炎、肺炎支原体肺炎、哮喘等。腔功能，还可有效提升治疗效果。参考文献1顾美玲,陆佳红,马苗苗,等.雌激素软膏联合电刺激与生物反馈治疗围绝经期性功能障碍的疗效观察J.浙江临床医学,2019,21(1):74-76.2梁建好,罗一平,陈翠玲.电刺激生物反馈联合盆底肌肉功能锻炼康复治疗女性盆底功能障碍的效果分析J.中外医学研究,2020,18(17):174-176.3林静丽,曾黎贞,林淑娟.生物反馈治疗仪联合康复锻炼对产妇盆底肌力及盆底功能障碍的影响J.医疗装备,2020,33(11):167-168.4吴辉,唐红.Prolift全盆底重建术联合雌激素治疗老年女性重度盆腔器官脱垂的疗效及对患者盆底功能的影响J.中国妇幼保健,2019,34(3):708-710.5许莉莉,赵仁峰.阴道涂抹雌激素联合盆底康复治疗对全子宫切除术后患者性生活质量的影响J.广西医学,2019,41(14):1737-1741.6刘敏,张冬霞.阴道雌激素与盆底康复联合应用治疗女性压力性尿失禁的临床疗效及不良反应分析J.中国妇幼保健,2019,34(7):1496-1498.7ISMAIL S.Pelvic organ prolapse after subtotal and total hysterectomy:a long-term follow-up of an open randomised controlled multicentre studyJ.BJOG,2014,121(12):1578-1579.8王小燕,王雪梅,王培霞.生物反馈电刺激联合雌激素类药物治疗女性盆底功能障碍的临床效果J.上海医药,2018,39(7):31-32,76.9LI C B,GONG Y P,WANG B.The efficacy of pelvic floor muscle training for pelvic organ prolapse:a systematic review and meta-analysisJ.Int Urogynecol J,2016,27(7):981-992.10KEPENEKCI I,KESKINKILIC B,AKINSU F,et al.Prevalence of pelvic floor disorders in the female population and the impact of age,mode of delivery,and parityJ.Dis Colon Rectum,2011,54(1):85-94.11许莉莉,赵仁峰.阴道涂抹雌激素联合盆底康复治疗对全子宫切除术后患者性生活质量的影响J.广西医学,2019,41(14):1737-1741.12吴辉,唐红.Prolift全盆底重建术联合雌激素治疗老年女性重度盆腔器官脱垂的疗效及对患者盆底功能的影响J.中国妇幼保健,2019,34(3):708-710.13陈彤,胡彬,张庆华.盆底康复联合雌孕激素应用于围绝经期妇女盆底功能障碍性疾病的作用研究J.中国妇幼保健,2014,29(18):2860-2861.14张保华,江怡,张善宝,等.丹莪妇康煎膏联合短期GnRH-a治疗对子宫内膜异立症患者术后复发的疗效观察J.医药论坛杂志,2020,41(4):9-12.临床治疗去乙酰毛花苷注射液联合米力农对小儿重症肺炎合并心衰的疗效及安全性分析李爽，田新磊，周怡锦，张辉果，朱珊河南省中医院(河南中医药大学第二附属医院)儿科，河南 郑州 450002摘要：目的 探讨去乙酰毛花苷联合米力农对小儿重症肺炎合并心衰的疗效。方法 选取河南省中医院 2021 年 1 月至2022年1月收治的89例重症肺炎合并心衰患儿。随机分为对照组45例和观察组44例，对照组采用去乙酰毛花苷治疗，观察组加用米力农，均治疗 5 d。比较两组治疗后的临床疗效、临床症状改善时间、临床指标，治疗前后的心功能指标 左室射血分数(LVEF)、左室收缩末径(LVDD)、房室瓣 EA 峰比值(E/A)、左室短轴缩短率(LVSF)、炎性因子水平 白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-(TNF-)及不良反应。结果 观察组临床疗效高于对照组，差异有统计学意义(P 0.05)。观察组各项临床症状改善时间均短于对照组，差异有统计学意义(P 0.05)。治疗后观察组心率低于对照组，差异有统计学意义(P 0.05)，血氧饱和度和尿量高于对照组，差异有统计学意义(P 0.05)。治疗后观察组 LVEF、E/A、LVSF 高于对照组，差异有统计学意义(P 0.05)，LVDD 低于对照组，差异有统计学意义(P 0.05)。治疗后观察组血清 IL-6、IL-8、TNF-水平低于对照组，差异有统计学意义(P 0.05)。两组不良反应差异无统计学意义(P 0.05)。结论 去乙酰毛花苷联合米力农疗效确切，可有效改善缓解重症肺炎合并心衰患儿临床症状，改善心功能，减轻机体炎症反应，且安全性较高。关键词：重症肺炎合并心衰；米力农；去乙酰毛花苷；心功能；安全性中图分类号：R563.1文献标志码：B DOI：10.12385/j.issn.2096-1278(2023)03-0096-04Efficacy and Safety Analysis of Deslanoside Injection Combined with Milrinone in the Treatment of Severe Pneumonia Complicated with Heart Failure in ChildrenLI Shuang,TIAN Xinlei,ZHOU Yijin,ZHANG Huiguo,ZHU ShanDepartment of Pediatrics,Henan Provincial Hospital of Traditional Chinese Medicine(The Second Affiliated Hospital of Henan University of Traditional Chinese Medicine),Zhengzhou Henan 450002,ChinaAbstract:Objective To investigate the effect of deslanoside combined with Milrinone on severe pneumonia complicated with heart failure in children.Methods A total of 89 children with severe pneumonia and heart failure admitted to Henan Hospital of Traditional Chinese Medicine from January 2021 to January 2022 were selected.The patients were randomly divided into the 97临床研究 2023 年 03 月第 31 卷第 03 期control group(45 cases)and the observation group(44 cases).The control group was treated with deslanoside,the milrinone was added to the observation group,and all patients were treated for 5 days.The clinical efficacy,improvement time of clinical symptoms,and clinical indicators of the two groups after treatment were compared.Cardiac function indexes left ventricular ejection fraction(LVEF),left ventricular final systolic diameter(LVDD),atrioventricular valve EA peak ratio(E/A),left ventricular short axis shortening rate(LVSF),infiammatory factor levels interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor-(TNF-)and adverse reactions were compared before and after treatment.Results The clinical effect of the observation group was higher than the control group,the difference was statistically significant(P 0.05).The improvement time of clinical symptoms in the observation group were shorter than that in the control group and the difference were statistically significant(P 0.05).After treatment,the heart rate of the observation group was lower than that of the control group,the difference was statistically significant(P 0.05),and the blood oxygen saturation and urine volume were higher than that of the control group,the difference was statistically significant(P 0.05).After treatment,LVEF,E/A,and LVSF in the observation group were higher than those in the control group,the difference was statistically significant(P 0.05),while LVDD was lower than that in the control group,the difference was statistically significant(P 0.05).After treatment,the serum levels of IL-6,IL-8,and TNF-in the observation group were lower than those in the control group,and the difference was statistically significant(P 0.05).There was no significant difference in adverse reactions between the two groups(P 0.05).Conclusion Deslanoside combined with milrinone has definite efficacy,can effectively improve and relieve the cl