东南大学学报(医学版)JSoutheastUniv(MedSciEdi)2022,Dec;41(6):824⁃830DAD,etal.ContributionofdysregulatedDNAmethylationtoautoimmunity[J].IntJMolSci,2021,22(21):11892⁃11911.[12]IACONAJR,MONTELEONENJ,LUTZCS.miR⁃146asup⁃presses5⁃lipoxygenaseactivatingprotein(FLAP)expressionandLeukotrieneB4productioninlungcancercells[J].Onco⁃target,2018,9(42):26751⁃26769.[13]BAGHERI⁃HOSSEINABADIZ,MIRZAEIMR,HAJIZADEHMR,etal.PlasmamicroRNAs(miR⁃146a,miR⁃103a,andmiR⁃155)aspotentialbiomarkersforrheumatoidarthritis(RA)anddiseaseactivityinIranianpatients[J].MediterrJRheumatol,2021,32(4):324⁃330.[14]KMIOLEKT,RZESZOTARSKAE,WAJDAA,etal.Thein⁃terplaybetweentranscriptionalfactorsandmicroRNAsasanimportantfactorforTh17/TregbalanceinRApatients[J].IntJMolSci,2020,21(19):7169⁃7186.[15]ERFANR,SHAKEROG,KHALILMAF,etal.Longnon⁃codingRNAPVT1anditstargetmiRNA⁃146aaspotentialprognosticbiomarkersinrheumatoidarthritispatients[J].Life(Basel),2021,11(12):1382⁃1395.[收稿日期]2022⁃04⁃13[修回日期]2022⁃06⁃02[基金项目]河北省科技计划项目(182777180)[作者简介]韩冰(1975),女,河北邯郸...