第41卷第1期2023年2月辐射研究与辐射工艺学报J.Radiat.Res.Radiat.Process.www.fs.sinap.ac.cnVol.41,No.1February2023蕨麻多糖对60Coγ射线辐射损伤小鼠的治疗作用吴代燕冯洋洋张琳梓刘前虔李杭雨央尖珍玛封海波（西南民族大学畜牧兽医学院成都610041）摘要选取48只小白鼠，随机分为8组，每组6只，1组为对照组，2、3、4组为给药组，5组为照射组，6、7、8组为照射给药组，1~4组不照射，5~8组用5Gy60Coγ射线照射，照后30~60min，1、5组和2~4、6~8组分别灌胃5d蒸馏水和蕨麻多糖，第6天处死小鼠，采集血液、肝脏、脾脏和股骨进行检测。结果显示，蕨麻多糖可以使辐射小鼠红细胞和白细胞数量、血红蛋白含量升高、红细胞比积增大，使脾脏指数、总抗氧化能力（T-AOC）、超氧化物岐化酶（SOD）的活性、淋巴细胞亚群比例上升，促进丙二醛（MDA）含量降低，一定程度提升辐射小鼠的DNA系数。蕨麻多糖对辐射损伤小鼠的造血系统、抗氧化系统和骨髓细胞DNA损伤具有较好的治疗效果。关键词60Coγ射线，蕨麻多糖，造血系统，抗氧化功能中图分类号R818.74，R811.5，R967，S859.3DOI:10.11889/j.1000-3436.2022-0080TherapeuticeffectofPotentillaanserinaLpolysaccharideonmiceinjuredby60CoγrayirradiationWUDaiyanFENGYangyangZHANGLinziLIUQianqianLIHangyuYANGJianzhenmaFENGHaibo(CollegeofAnimalHusbandryandVeterinaryMedicine,SouthwestMinzuUniversity,Chengdu610041,China)ABSTRACTForty-eightmicewererandomlydividedintoeightgroupsofsixmiceeach.Group1wasthecontrolgroup,groups2,3,and4werethePotentillaanserinaLdruggroups,group5wastheirradiationgroup,andgroups6,7,and8weretheirradiatedPotentillaanserinaLdruggroups.Thecontrolgroupwasadministereddistilledwaterbygavagefor5dwithoutirradiation;theirradiationgroupswereirradiatedwith5Gy60Coγrays.Inthedruggroups,themiceweregavagedwithdistilledwaterandPotentillaanserinaLpolysaccharidewithin30－60minafterirradiationfor5dandeuthanizedonthesixthday.TheeffectsofdifferentdosesofPotentillaanserinaLpolysaccharideonthebloodroutine,organindex,DNAcontentinbonemarrow,superoxidedismutase(SOD)activity,totalantioxidantcapacity(T-AOC),lymphocytesubpopulationratio,andmalondialdehyde(MDA)contentinthemouseliversweredetermined.TheresultsshowedthatPotentillaan...
