152第25卷第1期2023年1月辽宁中医药大学学报JOURNALOFLIAONINGUNIVERSITYOFTCMVol.25No.1Jan.,2023苦参药理作用研究进展马雪宁,杨素清,张君成,刘畅(黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040)基金项目:黑龙江省省级名中医专家传承工作室建设项目(G20191503)作者简介:马雪宁(1993-),女,黑龙江牡丹江人,博士在读,研究方向:中医药防治疑难性皮肤病的研究。通讯作者:刘畅(1981-),女,黑龙江哈尔滨人,副主任医师,硕士,研究方向:中医药防治疑难性皮肤病的研究。摘要:苦参为临床常用中药,具有清热燥湿、杀虫利尿功效。苦参的化学成分复杂,并且具有多种药理作用。该文对近年来苦参的化学成分以及药理作用进行综述,发现苦参的化学成分主要为氧化苦参碱、苦参碱以及黄酮类化合物,具有抗菌、抗病毒、降血糖、降血脂、抗氧化、抗炎、镇静、镇痛、抗肿瘤、免疫调节、保护心脏、抗生育等作用,为苦参的开发及临床应用提供理论依据。关键词:苦参;苦参碱;氧化苦参碱;药理作用;研究进展中图分类号:R285文献标志码:A文章编号:1673-842X(2023)01-0152-05ResearchProgressonPharmacologicalActionofKushen(SophoraeFlavescentisRadix)MAXuening,YANGSuqing,ZHANGJuncheng,LIUChang(TheFirstAffiliatedHospitalofHeilongjiangUniversityofTraditionalChineseMedicine,Harbin150040,Heilongjiang,China)Abstract:Kushen(SophoraeFlavescentisRadix)isatraditionalChinesemedicinecommonlyusedinclinic.Ithastheeffectsofclearingheat,dryingdampness,killinginsectsanddiuresis.ThechemicalconstituentsofKushen(SophoraeFlavescentisRadix)arecomplexandhaveavarietyofpharmacologicaleffects.ThispaperreviewsthechemicalcomponentsandpharmacologicaleffectsofKushen(SophoraeFlavescentisRadix)inrecentyears.ItisfoundthatthechemicalcomponentsofKushen(SophoraeFlavescentisRadix)aremainlyoxymatrine,matrineandflavonoids,whichhavetheeffectsofantibacterial,antiviral,hypoglycemic,hypolipidemic,antioxidant,anti-inflammatory,sedative,analgesic,antitumor,immuneregulation,heartprotectionandantifertility,soastoprovideatheoreticalbasisforthedevelopmentandclinicalapplicationofKushen(SophoraeFlavescentisRadix).Keywords:Kushen(SophoraeFlavescentisRad...