研究通讯Communication*E-mail:WangQA@hnu.edu.cn;xiawj@hit.edu.cnReceivedDecember7,2022;publishedJanuary11,2023.SupportinginformationforthisarticleisavailablefreeofchargeviatheInternetathttp://sioc-journal.cn.ProjectsupportedbytheNationalNaturalScienceFoundationofChina(No.21901141)andtheStart-upFundsofQuzhouUniversity(No.BSYJ201714).国家自然科学基金(No.21901141)和衢州学院科研启动基金(No.BSYJ201714)资助项目.ActaChim.Sinica2023,81,111—115©2023ShanghaiInstituteofOrganicChemistry,ChineseAcademyofScienceshttp://sioc-journal.cn111化学学报ACTACHIMICASINICA可见光促进(氮杂)芳香胺与重氮乙酸乙酯的N-烷基化反应赵亚婷a,b,c刘帆c汪秋安*,a夏吾炯*,c(a湖南大学化学化工学院长沙410000)(b衢州学院化学与材料工程学院衢州324000)(c哈尔滨工业大学(深圳)理学院深圳518055)摘要本工作利用可见光催化剂和Lewis酸双催化体系,在可见光条件下实现了重氮乙酸乙酯与苯胺衍生物或氮杂芳烃的N-烷基化反应,合成了一系列α-氨基酸类化合物.该反应条件温和,有良好的官能团兼容性和底物普适性.机理验证实验证明该反应涉及了自由基机理,由重氮烷在光催化剂作用下通过proton-coupledelectrontransfer(PCET)过程形成了烷基自由基,并在Lewis酸催化作用下与胺发生自由基偶联反应形成N-烷基化产物.这种新的催化机制进一步丰富了重氮化合物在可见光化学反应中的应用类型与范围.关键词可见光;重氮化合物;自由基;N-烷基化Visible-Light-PromotedN-AlkylationReactionsof(aza)AromaticAmineswithEthylDiazoacetateZhao,Yatinga,b,cLiu,FancWang,Qiuan*,aXia,Wujiong*,c(aCollegeofChemistryandChemicalEngineering,HunanUniversity,Changsha410000)(bCollegeofChemicalandMaterialEngineering,QuzhouUniversity,Quzhou324000)(cSchoolofScience,HarbinInstituteofTechnology(Shenzhen),Shenzhen518055)AbstractUnnaturalα-aminoacidderivativesaregreatlyimportantinpharmaceuticalsandbiochemicalsowingtotheirdiversebiologicalactivities,andusuallyserveasversatilebuildingblocksinorganicsynthesisaswell.Avarietyofap-proacheshavebeendevelopedtoprepareα-aminoacidderivatives,amongwhichN—Hinsertionreactionsofdiazocom-poundsareconsideredtobeoneofthemostdirectmethods.TheseN—Hinsertionreactionstypicallyproceedthr...
