2023年2月第30卷第2期甲状腺功能减退症患者血清Hcy、CRP表达水平及与心功能指标的相关性刘小晓1，王停2*（1湖北省枝江市人民医院检验科，湖北宜昌443200；2湖北省枝江市中医院检验科，湖北宜昌443200）【摘要】目的探讨甲状腺功能减退症患者血清Hcy、CRP表达水平及与心功能指标的相关性。方法纳入70例甲状腺功能减退症患者为患者组，70例健康体检者为对照组，比较两组的血清Hcy、CRP水平及心功能指标，分析血清Hcy、CRP与心功能指标的相关性。结果患者组的血清Hcy、CRP水平以及LVEDD、LVESD均显著高于对照组，LVEF显著低于对照组（P＜0．05）。Pearson相关分析显示，患者的血清Hcy、CRP水平与LVEDD、LVESD呈正相关，与LVEF呈负相关（均P＜0．05）。结论甲状腺功能减退症患者普遍存在血清Hcy、CPR水平过高及心功能下降情况，血清Hcy、CPR水平与患者的心功能指标具有密切联系。【关键词】甲状腺功能减退症；Hcy；CRP；心功能；相关性中图分类号：R581.2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.02.0197ExpressionLevelsofSerumHcyandCRPinPatientswithHypothyroidismandTheirCorrelationswithCardiacFunctionIndicators//LIUXiaoxiao1,WANGTing2*(1ClinicalLaboratory,ZhijiangPeople'sHospital,Yichang443200,China;2ClinicalLaboratory,ZhijiangHospitalofTraditionalChi-neseMedicine,Yichang443200,China;*Correspondingauthor:WANGTing,E-mail:mehe694940@163.com)[Abstract]ObjectiveToexploretheexpressionlevelsofserumHcyandCRPinpatientswithhypothyroidismandtheircorrelationswithcardiacfunctionindicators.Methods70patientswithhypothyroidismwereselectedasthepatientgroupand70healthysubjectswereselectedasthecontrolgroup.ThelevelsofserumHcyandCRP,andthecardiacfunctionindicatorsofthetwogroupswerecompared,andthecorrelationsofserumHcyandCRPwithcardiacfunctionindicatorswereanalyzed.ResultsThelevelsofserumHcyandCRP,LVEDDandLVESDinthepatientsgroupweresignificantlyhigherthanthoseinthecontrolgroup,andLVEFwassignificantlylowerthanthatinthecontrolgroup(P<0.05).Pearsoncorrelationanalysisshowedthatpatients'serumHcyandCRPlevelswerepositivelycorrelatedwithLVEDDandLVESD,andnegativelycorrelatedwithLVEF(allP<0.05).ConclusionsPatientswithhypothyroidismgenerallyhavehighserumHcyandCPRle...
