基于数据挖掘技术探析阴陵泉穴主治优势病症和配伍规律_李格.pdf

按摩与康复医学 2023年第14卷第3期 Chinese Manipulation and Rehabilitation Medicine,2023,Vol.14No.3基于数据挖掘技术探析阴陵泉穴主治优势病症和配伍规律基于数据挖掘技术探析阴陵泉穴主治优势病症和配伍规律*李格1，朱永政2，向玉元3，张振领3，贾红玲2，张永臣1，4（1.山东中医药大学，山东 济南 250014；2.山东中医药大学第二附属医院，山东 济南 250001；3.聊城大学，山东 聊城 252059；4.山东中医药大学附属医院，山东 济南 250014）摘摘要要 目的目的：运用数据挖掘技术，分析阴陵泉穴的优势病症与配伍处方，总结其主治特点与配伍规律。方法方法：在中国知网、万方学术期刊全文、维普中文期刊资源、SinoMed、Web of Science和PubMed等数据库中检索阴陵泉在1949-10-1到2022-3-31期间的相关资料，建立SQL Server数据库，运用“五输穴主治与配伍数据挖掘软件V1.0”及Gephi可视化软件对数据进行复杂网络、复合关联和聚类分析。结果结果：共纳入文献548篇。阴陵泉共6种单穴主治病症，优势病症包括肩关节周围炎和尿潴留；133种配伍主治病症，优势病症包括尿潴留、膝关节炎、糖尿病和脑卒中后遗症等19种。高频腧穴包括三阴交、足三里、血海、阳陵泉和关元等30穴。配伍经脉以足阳明胃经、足太阴脾经和任脉等为主。复合关联经筛选后得出45条阴陵泉配伍的腧穴-病症关联规则。聚类分析产生了3类7组高频配伍穴类组合。结论结论：阴陵泉主治方面主要以腧穴所在部位之膝关节炎、经脉所过部位之肢体关节病症、脾胃系及肾系相关脏腑病症和湿邪所致病症等为主，腧穴配伍主要以本经、交接经和表里经等方式为主，其结果可为临床和科研提供参考。关键词关键词 阴陵泉穴；数据挖掘；腧穴配伍；复合关联；聚类分析 中图分类号中图分类号 R R246246.9 9 文献标识码文献标识码 A A 文章编号文章编号 10081008-18791879(20232023)0303-00360036-0505DOIDOI：1010.1978719787/j/j.issnissn.10081008-18791879.20232023.0303.011011Analysis of Disease Syndromes and Compatibility Laws of YinLingQuanAnalysis of Disease Syndromes and Compatibility Laws of YinLingQuan(SPSP9 9)Point Based on Data Mining TechnologyPoint Based on Data Mining TechnologyLI Ge1,ZHU Yong-zheng2,XIANG Yu-yuan3,ZHANG Zhen-ling3,JIA Hong-ling2,ZHANG Yong-chen1,4(1.Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014;2.The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014;3.Liaocheng University,Liaocheng,Shandong 252059;4.Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,Shandong 250014)AbstractObjectiveAbstractObjective:To explore the dominant diseases and prescriptions of Yinlingquan(SP 9)and summarize its main treatment characteristics andprescription rules by using data mining technology.MethodsMethods:The relevant literatures regarding Yinlingquan from 1949-10-1 to 2022-3-31 were collected by computer retrieval at CNKI,WF,VIP,SinoMed,Web of Science,PubMed,etc.The SQL Server database was established.Then,the complex network analysis was conducted by using Gephi software.With the aid of data mining software V1.0 version of Wushu point indications andcompatibility,composite association and clustering analysis were completed.ResultsResults:A total of 548 literatures were included,in which there were 6kinds of single-point indications and 133 kinds of compatible acupoints indications.Among the single-acupoint indications,there were 2 dominantones,including scapulohumeral periarthritis and urinary retention.Among the compatible acupoints indications,there were 19 dominant ones,including urinary retention,knee arthritis,diabetes,sequelae of stroke,etc.High-frequency acupoints included 30 acupoints such as Sanyinjiao(SP6),Zusanli(ST36),Xuehai(SP10),Yanglingquan(GB34),Guanyuan(RN4),etc.The main compatible meridians were Stomach Meridians,Spleen Meridians,Conception Vessel,etc.45 association rules of acupoints-diseases were obtained by composite association.The results of hierarchic cluster analysisshowed that the 3 groups of acupoint prescriptions could be subdivided into 7 groups.ConclusionConclusion:According to the data mining analysis of modernliterature,the dominant diseases of Yinlingquan are mainly knee arthritis at acupoints,limb joint diseases at meridians,viscera diseases related tospleen and stomach system and kidney system,and diseases caused by dampness.And the main compatibility modes are the original meridian,coupling meridians and the exterior and interior meridians.The results can provide reference for clinical and scientific research.KeywordsKeywordsYinlingquan(SP9);data mining;compatibility of acupoints;composite association;clustering analysis阴陵泉，见于 灵枢 的 四时气，即“飧泄，补三阴之上，补阴陵泉，皆久留之，热行乃止”，别名“阴之陵泉”，见于 灵枢 的 九针十二原，即“疾高而内者，取之阴之陵泉”。后世 子午流注说难1中解释道：“阴陵泉乃脾合水穴，脾为阴中之至阴，陵高于丘也，泉高之处水流也。阴，水也。陵，土丘也。泉，水泉穴也。”中医药类数据挖掘研究日趋新高，在临床病证2、刺灸法3与腧穴研究4等领域成果颇丰。现代文献对阴陵泉的论述虽多，但对其主治疾病和腧穴配伍尚缺乏整体的归纳与分析。本文运用“五输穴 主 治 与 配 伍 数 据 挖 掘 软 件 V1.0（软 件 编 码：2022SR0024001）”及Gephi可视化软件，对现代阴陵泉相关文献进行统计学分析，旨在发现其主治优势病症和腧穴配伍规律，为临床和科研提供参考。1 1材料与方法材料与方法1.1 文献采集1.1.1 源文献采集 中文文献在知网、万方、维普和SinoMed 等数据库进行检索，国外文献在 PubMed、Web of Science等数据库进行检索；经查询阴陵泉别名为“阴之陵泉”，故中文以“阴陵泉”“阴之陵泉”为*基金项目基金项目：国家自然科学基金面上项目（编号:81973695）作者简介作者简介：李格（1997-），女，山东淄博人，2020级针灸推拿专业硕士研究生，研究方向：针灸学经典理论与临床应用。通讯作者通讯作者：张永臣（1968-），男，江苏丰县人，教授，博士研究生导师，研究方向：主要从事针灸学经典理论和临床应用研究。36第3期李格 等基于数据挖掘技术探析阴陵泉穴主治优势病症和配伍规律主 题 词 检 索；外 文 以“YinLingQuan”“YinZhiLingQuan”“SP9”为主题词检索。检索时限：1949-10-1至2022-3-31。1.1.2 纳入标准 以阴陵泉为主要治疗作用的单穴、配伍的针灸类临床文献；文献类型以疗效确切的随机对照研究、病例对照研究、队列研究和医案等为主；文献语种限定为中文、英文。1.1.3 排除标准 文章重复（只录入最早的文章）；文章存在明显错误或未给出明确治疗方案；涉及阴陵泉的临床随机对照研究，但其作为对照组一方或疗效不佳的相关文献；涉及动物实验、机制探讨与综述等内容的相关文献；涉及阴陵泉，但采用推拿手法进行治疗的相关文献；学位论文及会议论文。1.2 数据规范化1.2.1 腧穴名称规范 参照 经穴名称与定位(GB/T123462021）5经络腧穴学6等，规范阴陵泉及其配伍腧穴的名称，并对腧穴进行约简与分割处理，如将“阳陵泉透阴陵泉”分割为阳陵泉、阴陵泉。1.2.2 病症名称规范 参照 国际疾病分类第十一次修订本(ICD-11)中文版7、内、外、妇、儿、皮肤性病等8-15“十三五”规划教材对病名进行规范。如果教材无法概括病名，则以文章所描述病名为准。1.2.3 数据录入规范 相关条文的筛选规范，遵循“双人校对，第三人核实”的原则，提取相关信息并规范后录入SQL Server数据库。1.3 数据挖掘方式完成阴陵泉主治病症、配伍腧穴及经脉类别等数据统