临床医学研究与实践2023年3月第8卷第7期胃溃疡是一种常见的消化系统疾病，幽门螺杆菌感染、吸烟、慢性饮酒、精神因素和长期服用对胃黏膜有损害的药物是引起该病的常见病因[1-3]。目前，临床上治疗胃溃疡的药物主要有抗幽门螺杆菌药、H2受体阻断药、质子StudyontheactionmechanismofFeiyangChangweiyancapsulesintreatinggastriculcerbasedonnetworkpharmacologyTIANTian1,2,ZHOUDan3,FENGZhanbin3,LIUMingcui4,HUANGXiaoping5*(1.PharmacyDepartment,NinthHospitalofXi'an,Xi'an710054;2.SchoolofPharmacy,Xi'anJiaotongUniversity,Xi'an710061;3.CardiovascularHospital,NinthHospitalofXi'an,Xi'an710054;4.GynecologyandObstetricsDepartment,NinthHospitalofXi'an,Xi'an710054;5.GastroenterologyDepartment,NinthHospitalofXi'an,Xi'an710054,China)ABSTRACT:ObjectiveToexploretheactionmechanismofFeiyangChangweiyancapsulesintreatinggastriculcerbasedonnetworkpharmacology.MethodsThecomponentsofFeiyangChangweiyancapsuleswereretrievedandcollectedbyliteraturemethod,andthecomponentswerescreenedbySwissADME.TheSwissTargetPredictiondatabasewasusedtopredictthetargetofactivecomponents.TherelatedtargetsofgastriculcerwereobtainedbyGeneCardsandOMIMdatabase;theStringdatabasewasusedtoconstructprotein-proteininteraction(PPI)networkdiagram;theGeneOntology(GO)enrichmentanalysisandtheKyotoEncyclopediaofGenesandGenomes(KEGG)pathwayanalysiswereperformedbyDAVIDdatabase,andCytoscape3.8.0softwarewasusedtoconstructthenetworkdiagramof"FeiyangChangweiyancapsules-component-target-gastriculcer".ResultsThroughGeneCardsandOMIMdatabase,4958gastriculcerrelatedtargetgeneswereretrieved,and205FeiyangChangweiyancapsules-gastriculcerinteractivetargetswereobtainedbyintersection.Twelvemaincomponentsand301gastriculcerdiseasetargetswerescreened.TheresultsofnetworkanalysisshowedthatFeiyangChangweiyancapsulesinthetreatmentofgastriculcermayberelatedtoproteinphosphorylation,signaltransduction,responsetodrug,negativeregulationofapoptosisprocess,proteinautophosphorylationandotherbiologicalprocessesandPI3K-Akt,cAMP,AMPK,VEGFandothersignalingpathways.ConclusionFeiyangChan...
