2023年4月第30卷第4期埃索美拉唑与奥美拉唑治疗非甾体类抗炎药致老年上消化道出血的效果比较盘车莲，何元增，曾凡永（中山市东凤人民医院消化科，广东中山528425）【摘要】目的比较埃索美拉唑与奥美拉唑治疗非甾体类抗炎药（NSAIDs）致老年上消化道出血的临床效果。方法80例老年NSAIDs致上消化道出血患者根据用药方案的不同分为两组。在常规治疗基础上，对照组给予奥美拉唑治疗，观察组给予埃索美拉唑治疗。比较两组的治疗效果、止血时间、血红蛋白（HGB）水平及血小板（PLT）计数。结果治疗后，观察组的总有效率高于对照组，止血时间短于对照组，HGB水平及PLT计数均高于对照组（P<0.05）。结论埃索美拉唑治疗NSAIDs致老年上消化道出血的效果优于奥美拉唑，在缩短患者止血时间、提高患者HGB水平及PLT计数方面优势更为显著。【关键词】埃索美拉唑；奥美拉唑；非甾体类抗炎药；老年上消化道出血中图分类号：R573.2文献标识码：Adoi:10.3969/j.issn.1674-4659.2023.04.0475ComparisonontheEffectsofEsomeprazoleandOmeprazoleintheTreatmentofElderlyUpperGastrointestinalBleedingInducedbyNon-SteroidalAnti-InflammatoryDrugs//PANGChelian,HEYuanzeng,ZENGFanyong(DepartmentofGastroenterology,DongfengPeople'sHospital,Zhongshan528425,China)[Abstract]ObjectiveTocomparetheclinicaleffectsofesomeprazoleandomeprazoleinthetreatmentofelderlyuppergastrointestinalbleedinginducedbynon-steroidalanti-inflammatorydrugs(NSAIDs).Methods80elderlypatientswithuppergastrointestinalbleedinginducedbyNSAIDsweredividedintotwogroupsaccordingtodifferentmedicationregimens.Onthebasisofroutinetreatment,thecontrolgroupwastreatedwithomeprazole,andtheobservationgroupwastreatedwithesomeprazole.Thetherapeuticeffect,hemostasistime,hemoglobin(HGB)levelandplatelet(PLT)countwerecomparedbetweenthetwogroups.ResultsAftertreatment,thetotaleffectiverateoftheobservationgroupwashigherthanthatofthecontrolgroup,thehemostasistimewasshorterthanthatofthecontrolgroup,andtheHGBlevelandPLTcountwerehigherthanthoseofthecontrolgroup(P<0.05).ConclusionsEsomeprazolehasbettereffectthanomeprazoleinthetreatmentofelderlyuppergastrointestinalbleedinginducedbyNSAIDs,whichhasmoresignificantadvantagesinshorteningtheh...
