4·中国CT和MRI杂志2023年02月第21卷第02期总第160期【第一作者】陈煜豪，男，医师，主要研究方向：神经影像学。E-mail：674136562@qq.com【通讯作者】陈德基，男，教授，主要研究方向：放射诊断学与介入放射学。E-mail：chendeji2003@163.com论著ApplicationofDSC-PWIinGradingandKi-67ExpressionofGliomaCHENYu-hao,CHENDe-ji*,CHENMan,LIUBo,CHENHong,CHENSheng-jun.DepartmentofRadiology,theSecondAffiliatedHospitalofGuangzhouMedicalUniversity,Guangzhou510260,GuangdongProvince,ChinaABSTRACTObjectiveToexplorethedifferenceandcorrelationofDSC-PWIbetweenhigh-gradeandlow-gradegliomasandKi-67expressionintumors.MethodsWeselectedpatientswhowerepathologicallydiagnosedasgliomaandhadKi-67expressionindextestingastheresearchobjectsinourhospitalfromDecember2019toDecember2020.Inthisstudy,Philips3.0TMRscanningandpost-processingworkstationwereusedtoanalyzetheDSC-PWIsequenceandtoobservetherelationshipbetweentheperfusionparametervalueandthegliomagrade,aswellastheKi-67expressionandtheefficiencyoftest.ResultsAtotalof35patientswereselected.12patientswerelow-gradegliomasand23patientswerehigh-gradegliomas.Twogroupshadsignificantstatisticaldifference(P<0.01)andpositivecorrelation(P<0.01).ROCanalysisshowedthatrCBFandrCBVhavecertainpredictivevalueindifferentiatinglow-gradeandhigh-gradegliomasandKi-67expression.Inthisstudy,rCBF=2.33,rCBV=2.10werethecut-offvaluefordistinguishinglow-gradeandhigh-gradegliomaswhilerCBF=2.33,rCBV=2.16werethecut-offvalueforjudgingtheexpressionlevelofKi-67.ThestudyalsofoundthatrCBVvalueswerebetterthantherCBFvaluesfortheidentificationofhigh-gradeandlow-gradegliomaspreoperativeclassificationandthejudgmentoftheexpressionofKi-67.ConclusionDSC-PWItechniqueisofgreatsignificanceforthepreliminaryassessmentofgliomagradeandKi-67expression.Keywords:DSC-PWI;PerfusionParameters;Glioma;Ki-67脑胶质瘤起源于神经胶质细胞或干细胞[1]。在病理学中，镜下常可见迂曲走行、分布杂乱的新生血管，随着肿瘤进一步生长，新生血管会逐渐生长增多[2]，能在一定程度上反映出胶质瘤的生长特性[2]。有资料显示，Ki-67抗原的表达亦常用于判...
