《2022JSC/JSTDM临床实践指南:替考拉宁治疗药物监测》解读王润红河哈尼族彝族自治州中医医院(红河654399)【摘要】目的为临床合理使用替考拉宁以及更好地管理接受替考拉宁治疗的患者。方法从药学角度对2022年日本《2022JSC/JSTDM临床实践指南:替考拉宁治疗药物监测》(简称《指南》)涉及替考拉宁治疗的9个临床问题进行解读。结果《指南》指出药-时曲线下面积/最小抑菌浓度是替考拉宁的关键药动学/药效学参数。替考拉宁治疗药物监测(TDM)的目的是明确目标谷浓度(Cmin),对于严重或复杂的耐甲氧西林金黄色葡萄球菌(MRSA)感染,指南建议替考拉宁Cmin为20~40mg/L。肾功能正常或轻度受损的非复杂性的MRSA感染,目标Cmin为15~30mg/L。严重和/或复杂性MRSA感染,如感染性心内膜炎和骨髓炎,替考拉宁Cmin为20~40mg/L。结论《指南》针对不同病理状态下患者替考拉宁目标Cmin的确定,为临床治疗中替考拉宁TDM、个体化给药提供参考。【关键词】替考拉宁;治疗药物监测;耐甲氧西林金黄色葡萄球菌;指南解读;目标谷浓度DOI:10.3969/j.issn.1000-8535.2023.02.004InterpretationofClinicalpracticeguidelinesfortherapeuticdrugmonitoringofteicoplanin:aconsen-susreviewbytheJapaneseSocietyofChemotherapyandtheJapaneseSocietyofTherapeuticDrugMonitoringWANGRunHongheHaniandYiAutonomousPrefectureHospitalofTraditionalChineseMedicine,Honghe654399,China【Abstract】ObjectiveTomakerationaluseofteicoplaninandbettermanagementofpatientstreatedwithteicopla-nin.MethodsNineclinicalissuesrelatedtothetreatmentofteicoplanininClinicalpracticeguidelinesfortherapeuticdrugmonitoringofteicoplanin:aconsensusreviewbytheJapaneseSocietyofChemotherapyandtheJapaneseSocietyofTherapeuticDrugMonitoring(Japan,2022)wereinterpretedfromtheperspectiveofpharmacy.ResultsTheguidelinesindicatedthattheareaunderdrug-timecurve/minimuminhibitoryconcentrationwasthekeypharmacokinetic/pharmacodynamicparametersofteicoplanin.Thepurposeoftherapeuticdrugmonitoring(TDM)ofteicoplaninistospecifythetargettroughconcentration(Cmin),whichguidelinesrecommendforsevereorcomplexmethicillin-resistantStaphylococcusaureus(MRSA)infectionis20-40mg/L.ThetargetCminforuncomplicatedMRSAinfectionwithnormalormildlyimpairedrenalfunctionis15-30mg/L.Fo...
