抗病毒药物是一种可直接抑制或杀灭病毒、抑制生物合成、增强宿主抗病毒能力的药物[1-2].与传统口服药物一样，抗病毒药物可以通过粪便或尿液排出，但污水处理厂对抗病毒药物的去除效率有限，所以这些药物会通过污水处理厂排水进入水环境中.尽管抗病毒药物的环境浓度很低，但根据定量构效关系模型和毒性数据可知[3-5]，它们对藻类、水蚤和鱼类存在潜在威胁.除对水生生物有毒性外，抗病毒药物还可能导PhotolysiskineticsofthreeantiviraldrugsinwaterWANGTao1，2，WUYingxin1，2，MENGLingchen2，ZOUHongyan1，2（1.TianjinKeyLaboratoryofWaterResourcesandEnvironment，TianjinNormalUniversity，Tianjin300387，China；2.SchoolofGeographicandEnvironmentalSciences，TianjinNormalUniversity，Tianjin300387，China）Abstract：Inordertolearnthephotolysiskineticsofantiviraldrugsinwaterandtheeffectsofdifferentenvironmentalconditions,asimulatedsunlightexperimentwascarriedoutwithabacavir（ABV），entratabine（ETB）andzidovudine（ZDV）asresearchobjects.Theresultsshowedthat①ThephotolysisofETBandZDVweremainlydominatedbydirectphotolysis，whilethephotolysisofABVwasmainlybyindirectphotolysis；②ThedegradationratesofETBandZDVinfreshwaterwerelowerthanthatinpurewater，buthigherthanthatinseawater，whileABVhadacompletelyoppositetrend；③NO3-couldsignificantlypromotethephotolysisofthethreeantiviraldrugs.NO2-hadnoobviouseffectsonthephotolysisofETBandZDV，butcouldsignificantlydecreasethereactionrateofABV；④CO3-andHCO3-inhibitedthephotolysisofthethreedrugstodifferentdegrees；⑤Dissolvedorganicmatter（DOM）couldpromotethephotolysisofABV，butcouldinhibitthephotolysisofETBandZDV；⑥NH4+andSO42-hadnoobviouseffectsonthephotolysisofETBandZDV，butcouldsignificantlyenhancethephotoly-sisofABV；⑦HalogenionscouldinhibitthephotolysisofETBandZDVtosomeextent，butcouldpromotethephotolysisofABV；⑧ABVcouldundergoself-sensitizedphotolysisinadditiontodirectphotolysisandindirectphotolysis.Keywords：antiviraldrugs；photolysiskinetics；directphotolysis；indirectphotolysis；selfsensitizedphotolysis3种抗病毒药物在水中的光解动力学汪涛1，2，武英欣1，2，孟令辰2，...
