第53卷第2期2023年2月Vol.53No.2Feb.2023·171·日用化学工业（中英文）ChinaSurfactantDetergent&CosmeticsReceived:April3,2022;Revised:February6,2023.*Correspondingauthor.E-mail:peipei.wang@robustnique.com.2021年天津市生物医药科技重大专项（21ZXSYSY00010）DOI：10.3969/j.issn.1001-1803.2023.02.007StudyonskincareefficacyofAIMP1derivedpeptideXiufenYang1,WenjunMa1,LeiLi1,PeipeiWang1,*,ChunyangZheng1,2（1.RobustniqueCorporationLtd.,Tianjin300384,China;2.IntegribiotechCorporationLtd.,Tianjin300384,China）Abstract:Advancedglycationend-products（AGEs）areproducedduringproteinglycationandassociatedwithskinageing.TheAIMP1derivedpeptide（AdP）whichisderivedfromaminoacyltRNAsynthaseinteractingmultifunctionalprotein1maybeusedasaninhibitorofglycation.Thisstudyevaluatedthepotentialanti-glycationeffectofAdPanditsapplicationincosmetic.Thirtyvalidsubjectswereselectedastheresearchsubjects,andnon-invasiveinstrumentswereusedtodetectandrecordthewatercontent,TEWL,R2,ITA°,wrinklearea/AOIareainthetestgroupandthecontrolgroupat0,4and8weeksusingcorrespondingproducts.TheresultsshowthattheglycosylationreactionbetweenBSAandglucoseisinhibitedbyAdP,andtheformationofproteincarbonylisreducedinaconcentration-dependentmanner.TheapplicationsofAdPincosmetichassignificanteffectsonimprovingthestratumcorneumwatercontent,theR2value,theITA°value,andthereducingtheTEWLvalueandwrinkles.ThesefindingssuggestthatAdPmayserveasaninhibitorofglycationandprovidenewinsightsintoitsapplication.Keywords:AIMP1derivedpeptide;anti-glycosylation;efficacystudy48h24h0.5h0.02%SLS0.1%AdP0.01%AdPDistilledwater0.05%AdPRepresentativeimagesofAdPhumanpatchtestBaseline8WeeksRepresentativeimagesofskincolorimprovementbeforeand8weeksafterAdPtreatmentEffectofAdPonmalondialdehyde-inducedformationofproteincarbonylgroups0.5A450AdPMassconcentration/(mg/mL)0.40.30.20.100.511.522.533.5fffffedcba4·172·第53卷开发与应用日用化学工业（中英文）糖化反应（Glycation）全称非酶糖基化（Non-enzymaticglycation,NEG），是指还原糖上的羰基与蛋白质、脂质或核酸等大...
