广西医科大学学报JOURNALOFGUANGXIMEDICALUNIVERSITY2023Jan；40（1）Dectin-1在宿主抗隐球菌感染的机制与研究进展*于柯瑶，张克明，黄越，廖万清△，潘炜华△（海军军医大学第二附属医院皮肤科，上海200003）摘要固有免疫在隐球菌感染中发挥着至关重要的作用，宿主建立对隐球菌有效免疫应答的第一步是通过固有免疫应答细胞表达的模式识别受体（PRR）识别隐球菌病原体相关分子模式（PAMP），进一步触发涉及许多蛋白质（脾酪氨酸激酶和胱天蛋白酶募集域蛋白9等）的细胞内信号级联反应。本篇综述中笔者总结了固有免疫应答细胞模式识别受体Dectin-1与隐球菌病原体相关分子模式的相互识别机制，并讨论了Dectin-1信号通路在宿主抗隐球菌感染免疫中的作用及其在隐球菌病药物和疫苗佐剂研发中的潜在应用。关键词隐球菌；Dectin-1；受体；天然免疫；抗原递呈细胞中图分类号：R519.4文献标志码：A文章编号：1005-930X（2023）01-0001-05DOI：10.16190/j.cnki.45-1211/r.2023.01.001MechanismandresearchprogressofDectin-1againstcryptococcalinfectioninhostYuKeyao,ZhangKeming,HuangYue,LiaoWanqing,PanWeihua.(DepartmentofDermatology,SecondAffiliat-edHospitalofNavalMedicalUniversity,Shanghai200003,China)AbstractInnateimmunityplaysacrucialroleincryptococcalinfection.Thefirststepforthehosttoestablishaneffectiveimmuneresponsetocryptococcalinfectionistorecognizethecryptococcalpathogen-associatedmo-lecularpatterns(PAMP)throughpatternrecognitionreceptors(PRR)expressedbyinnateimmuneresponsecells.Thenintracellularsignalingcascadesaretriggeredinvolvingmanyproteins(splenictyrosinekinaseandcaspaserecruitmentdomain-containgprotein9,etc.).Inthisreview,wesummarizethemutualrecognitionmechanismbe-tweentheinnateimmuneresponsecellpatternrecognitionreceptorDectin-1andcryptococcalpathogen-associat-edmolecularpatterns,anddiscusstheroleofDectin-1signalingpathwayinhostimmunityagainstcryptococcalinfectionanditspotentialapplicationinthedevelop-mentofcryptococcaldrugsandvaccineadjuvants.KeywordsCryptococcus;Dectin-1;recipient;natu-ralimmunity;antigenpresentingcell*基金项目：中国工程院战略研究与咨询项目（No.2022-HZ-10-03）△通信作者，廖万清，E-mail：liaowanqing@sohu.com；潘炜华，...
