《中国肿瘤临床》文章推荐：...床诊治新进展——机遇和挑战.pdf

15(11):e0242809.Nielsen MS,Axelsen LN,Sorgen PL,et al.Gap junctionsJ.ComprPhysiol,2012,2(3):1981-2035.17 Schajnovitz A,Itkin T,DUva G,et al.CXCL12 secretion by bonemarrow stromal cells is dependent on cell contact and mediatedby connexin-43 and connexin-45 gap junctionsJ.Nat Immunol,2011,12(5):391-398.18 Kouzi F,Zibara K,Bourgeais J,et al.Correction:Disruption of gapjunctions attenuates acute myeloid leukemia chemoresistance in-duced by bone marrow mesenchymal stromal cellsJ.Oncogene,2020,39(10):2227.19 Caivano A,La Rocca F,Laurenzana I,et al.Extracellular vesicles inhematological malignancies:from biology to therapyJ.Int J MolSci,2017,18(6):E1183.20 Trino S,Lamorte D,Caivano A,et al.Clinical relevance of extracel-lular vesicles in hematological neoplasms:from liquid biopsy tocell biopsyJ.Leukemia,2021,35(3):661-678.21 Nehrbas J,Butler JT,Chen DW,et al.Extracellular vesicles andchemotherapy resistance in the AML microenvironmentJ.FrontOncol,2020,10:90.22 Lyu TX,Wang YN,Li D,et al.Exosomes from BM-MSCs promoteacute myeloid leukemia cell proliferation,invasion and chemores-istance via upregulation of S100A4J.Exp Hematol Oncol,2021,10(1):24.23 Viola S,Traer E,Huan JY,et al.Alterations in acute myeloid leuk-aemia bone marrow stromal cell exosome content coincide withgains in tyrosine kinase inhibitor resistanceJ.Br J Haematol,2016,172(6):983-986.24 XuYC,Lin YS,Zhang L,et al.microRNAs of bone marrow mesen-chymal stem cell-derived exosomes regulate acute myeloid leuk-emia cell proliferation and apoptosisJ.Chin Med J(Engl),2020,133(23):2829-2839.25 Cheng H,Ding J,Tang GS,et al.Human mesenchymal stem cellsderived exosomes inhibit the growth of acute myeloid leukemiacells via regulating miR-23b-5p/TRIM14 pathwayJ.Mol Med,2021,27(1):128.26 Zhang F,Lu Y,Wang M,et al.Exosomes derived from human bonemarrow mesenchymal stem cells transfer miR-222-3p to suppressacute myeloid leukemia cell proliferation by targeting IRF2/INPP4BJ.Mol Cell Probes,2020,51:101513.27 Zhang L,Khadka B,Wu JY,et al.Bone marrow mesenchymal stemcells-derived exosomal miR-425-5p inhibits acute myeloid leuk-emia cell proliferation,apoptosis,invasion and migration by tar-geting WTAPJ.Onco Targets Ther,2021,14:4901-4914.28 Moschoi R,Imbert V,Nebout M,et al.Protective mitochondrialtransfer from bone marrow stromal cells to acute myeloid leukem-ic cells during chemotherapyJ.Blood,2016,128(2):253-264.29（2022-05-30 收稿）（编辑：孙喜佳校对：郑莉）作者简介司君齐 专业方向为淋巴瘤及白血病的诊治与研究。E-mail：S 读者作者编者中国肿瘤临床文章推荐：BRCA1/2 突变乳腺癌临床诊治新进展机遇和挑战BRCA1 和 BRCA2 是乳腺癌迄今最常见的两个高外显率易感基因。BRCA1/2 胚系突乳腺癌具有特殊的发病机制及临床病理特征，其临床决策有别于散发性乳腺癌。随着基因测序技术的发展，越来越多的 BRCA1/2突变乳腺癌被检测出。BRCA1/2 突变乳腺癌的相关临床管理越来越得到重视。为此，2021 年第 49 卷第 23 期中国肿瘤临床的家族遗传性肿瘤专栏-专家论坛栏目刊发了由北京大学肿瘤医院家族遗传性肿瘤中心主任解云涛教授撰写的BRCA1/2 突变乳腺癌临床诊治新进展机遇和挑战一文,该文总结近年来的相关文献，对 BRCA1/2 突变乳腺癌患者的基因检测和手术、化疗、靶向治疗等诊疗进展进行综述，以期为 BRCA1/2 突变患者的临床决策提供帮助。阅读本文请登录网站 或关注本刊微信公众号（扫描文章下方二维码）查看。中国肿瘤临床 2023 年第 50 卷第 2 期Chin J Clin Oncol 2023.Vol.50.N91