P_O_LC_W多重乳状液的制备及性能研究（英文）_吕雅文.pdf

第 53 卷 第 2 期2023 年 2 月Vol.53 No.2Feb.2023121 日 用 化 学 工 业（中英文）China Surfactant Detergent&CosmeticsReceived:March 10,2022;Revised:January 28,2023.*Corresponding author.E-mail:.国家自然科学基金：表面活性剂的界面传递行为研究（No.21476072）DOI：10.3969/j.issn.1001-1803.2023.02.001Preparation of P/O/LC/W multiple emulsionYawenLv,JingwenWang,ZhichengYe,YazhuoShang*,HonglaiLiu（Laboratory of Cosmetics,School of Chemistry&Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China）Abstract:A type of polyol-in-oil-in-liquid crystal-in-water（P/O/LC/W）multiple emulsion was prepared by two-step method with liquid crystal emulsifier and traditional emulsifier.The samples were characterized by microscopy.The effects of different liquid crystal emulsifiers,emulsification temperature and homogenization rate on the microstructure of P/O/LC/W multiple emulsion were studied.The steps of preparation process were as follows:The emulsification temperature was 60-75;the homogenization rate of polyol in oil was 7 000-8 400 r/min and homogenization time was 6 min;the homogenization rate of polyol in oil in liquid crystal in water was 4 400-6 000 r/min and homogenization time was 7 min.The emulsion was put at room temperature for 28 days,and multiple structures and liquid crystal structures could still be observed,and the liquid crystal became brighter.The components of the formula were glycerol（polyol phase）,squalane（oil phase）,P135（hydrophobic emulsifier）,and IST-LC001（liquid crystal emulsifier）.The ideal emulsion structure could thus be obtained.The formula was used to encapsulate active substances.Resveratrol was used as the target molecule for sustained-release experiment.The results of dialysis experiments in vitro showed that the P/O/LC/W multiple emulsion had a remarkable slow-release performance.The release ratio of target molecule was up to 83%after 10 h.When shikonin was used as the target molecule,it was proved that the P/O/LC/W multiple emulsion could mask the color of the target molecule.Compared with traditional emulsion,the color of P/O/LC/W multiple emulsion was lighter.Rheological measurement showed that the viscosity of the emulsion decreased with the increase of shear stress,indicative of positive thixotropy.Within the investigated range,the storage modulus of the emulsion was always higher than that of loss modulus,exhibiting elastic properties.The internal structure of the emulsion was stable and the emulsion could bring good skin feel to skin care products.The experimental results showed that,the P/O/LC/W multiple emulsion could not only solve the problems in application of insoluble functional ingredients in formulations,but also effectively deliver these active substances and achieve slow-release.The emulsion could also mask the color of introduced ingredients and improve the skin feel of products.The P/O/LC/W multiple emulsion has wide application value in the fields of medicine,food,cosmetics,etc.Key words:multiple emulsion;lamellar liquid crystal emulsion;polyol;slow releaseLiquid CrystalEmulsifierP/OEmulsionOil+W/O EmulsifierP/O/LC/WEmulsionWaterpolyolsPrimaryHomogenzationSecondHomogenzation122第 53 卷基 础 研 究日 用 化 学 工 业（中英文）As the pace of life accelerates,irregularities in lifestyle combined with environmental factors such as UV rays and air-borne dust have caused damage to skin.More and more people are facing skin problems and beginning to pay attention to skin care products.Many factors can influence the efficacy of a skin care product,such as ingredients,individual skin differences,formulations,and dosage forms.Among these factors,a suitable dosage form can provide maximum effectiveness of active ingredients.Multiple emulsion is a complex emulsion system.There are two main types of multiple emulsions,i.e.,oil-in-water-in-oil（O/W/O）and water-in-oil-in-water（W/O/W）.Multiple emulsions can encapsulate volatiles,hydrophilic compounds,and hydrophobic compounds 1-4.There are many factors that could affect the stability of a multiple emulsion due to its own kinetic and thermodynamic properties,which limit its practical application in everyday life 5.Polyol-in-oil-in-water（P/O/W）multiple emulsion is a new kind of multiple emulsion.Zhu Dan et al 6 have replaced the internal aqueous phase in W/O/W multiple emulsion with polyols and successfully encapsulated vitamin C.Compared to traditional multiple emulsions,using polyols as an internal phase can not only improve the poor solubility of some active ingredients in water but also reduce the risk of oxidative degradation.In addition,the higher viscosity of the polyol itself contributes to the stability of the multiple emulsion.So far,as a new type of carriers,P/O/W multiple emulsions,including their stability and emulsion properties,have not been systematically studied.Liquid crystal emulsion is one of the current research hotspots.Liquid crystal emulsion has been used in skin care products in recent years.It has an excellent skin feel and good stability 7-9.It a