_STP_1396-2000.pdf

STP 1396 Synthetic Bioabsorbable Polymers for Implants C.Mauli Agrawal,Jack E.Parr,and Steve T.Lin,editors ASTM Stock Number:STP1396 ASTM 100 Barr Harbor Drive PO Box C700 West Conshohocken,PA 19428-2959 Printed in the U.S.A.Library of Congress Cataloging-in-Publication Data Synthetic bioabsorbable polymers for implants C.Mauli Agrawal,Jack E.Parr,and Steve T.Lin,editors.p.cm.-(STP;1396)ASTM Stock Number:STP1396.Includes bibliographical references.ISBN 0-8031-2870-3 1.Polymers in medicinc Congresses.2.Biomedical engineering-Congresses.3.Biomedial matedals-Congresses.I.Agrawal,C.Mauli(Chandra Mauli)I1.Parr,Jack E.II1.Lin,Steve T.,1947-IV.ASTM special technical publication;1396.R857.P6$954 2000 610.28-dc21 00-040612 Copyright?9 2000 AMERICAN SOCIETY FOR TESTING AND MATERIALS,West Conshohocken,PA.All rights reserved.This material may not be reproduced or copied,in whole or in part,in any printed,mechanical,electronic,film,or other distribution and storage media,without the written con-sent of the publisher.Photocopy Rights Authorization to photocopy items for internal,personal,or educational classroom use,or the internal,personal,or educational classroom use of specific clients,is granted by the American Society for Testing and Materials(ASTM)provided that the appropriate fee is paid to the Copyright Clearance Center,222 Rosewood Drive,Danvers,MA 01923;Tel:978-750-8400;on-line:http:# Review Policy Each paper published in this volume was evaluated by two peer reviewers and at least one editor.The authors addressed all of the reviewers comments to the satisfaction of both the technical editor(s)and the ASTM Committee on Publications.To make technical information available as quickly as possible,the peer-reviewed papers in this publication were prepared=camera-ready as submitted by the authors.The quality of the papers in this publication reflects not only the obvious efforts of the authors and the technical editor(s),but also the work of the peer reviewers.In keeping with long-standing publica-tion practices,ASTM maintains the anonymity of the peer reviewers.The ASTM Committee on Publications acknowledges with appreciation their dedication and contribution to time and effort on behalf of ASTM.Printed in Scranton,PA July 2000 Foreword This publication,Synthetic Bioabsorbable Polymers for Implants,contains papers presented at the symposium of the same name held in Kansas City,Missouri,on 16-17 November 1999.The sympo-sium was sponsored by ASTM Committee F4 on Medical and Surgical Materials and Devices.The symposium co-chairmen were C.Mauli Agrawal,The University of Texas Health Science Center,Jack E.Parr,Wright Medical Technology,Inc.,and Steve T.Lin,Exactech,Inc.Contents Overview Mechanical Evaluation of 70:30 Poly(L/DL-Lactide)Bone Screws After In Vitro Degradation-J.A.DISEGI,J.W.DWYER,AND R.E.FAIRER Evaluation of Adhesive and Absorption Properties for Absorbable Tissue Adhesives-J.M.ALLAN,J.A.FLALE,J.D.KLINE,R.L.DOOLEY,AND S.W.SHALABY Bacterial Polyesters for Biomedical Applications:In vitro and in vivo Assessments of Sterilization,Degradation Rate and Biocompatihility of Poly(3-gydroxyoctaanoate)(PHO)-Y.MAROIS,Z.ZHANG,M.VERT,X.DENG,R.W.LENZ,AND R.GUIDOIN Novel Biodegradable Polyurethanes for Medical Applications-K.GORNA AND s.GOGOLEWSra Effects of Thermal History and Physical Aging on Thermal Properties of Poly-L-Lactide.-M.DENG,J.M.ALLAN,J.T.CORBETI,AND S.W.SHALABY Resorption Profile and Biological Response of Calcium Phosphate filled PLLA and PI-IB7V-N.L.JONES,J.J.COOPER,R.D.WATERS,AND D.F.WILLIAMS The Clinical Evaluation of a Bioresorbable Minipin-D.w.HUTMACHER,A.KIRSCH,K.L.ACKERMANN,H.LIEDTKE,AND M.B.HLRZELER The Use of the Vibrating Particle Technique to Fabricate Highly Porous And Permeable Biodegradable Scaffolds-c.M.AGRAWAL,J.S.MCKINNEY,D.HUANG,AND K.A.ATHANASIOU Modulation of Pore Topography of Tissue Engineering Constructs-K.J.L.BURG,C.E.AUSTIN,AND J.P.SWlGGETT In Vitro Compression Testing of Fiber-Reinforced,Bioabsorbable,Porous Implants-M.A.SLIVKA,N.C.LEATHERBURY,K.KIESWETTER,AND G.G.NIEDERAUER Clinical Evaluation of a Bioresorbable Membrane for Hard Tissue Regeneratiow-D.W.HUTMACHER,A.KIRSCH,K.L.ACKERMANN,AND M.B.HORZELER 12 39 58 69 83 99 115 124 136 Design and Fabrication of a 3D Scaffold for Tissue Engineering Bone-D.W.HUTMACHER,S.H.TEOH,1.ZEIN,K.W.NG,J.T.SCHANTZ,AND J.C.LEAHY 152 Overview Over the past decade,the use of synthetic bioabsorbable polymers in the field of medicine has grown steadily,and it is not uncommon today to find bioabsorbable devices commercially available for use as implants.The popularity of bioabsorbable polymers in medicine stems from the fact that implants fabricated from these materials are absorbed by the body over time.Moreover,the rate of absorption can be designed to meet the needs of the application.This is a significant advantage because nonab-sorbable implants often have to be removed surgically after tissue healing has occurred.Also,most synthetic bioabsorbabl