ASTM_E_2838_-_11.pdf

Designation:E283811Standard Test Method forDetermination of Thiodiglycol on Wipes by SolventExtraction Followed by Liquid Chromatography/TandemMass Spectrometry(LC/MS/MS)1This standard is issued under the fixed designation E2838;the number immediately following the designation indicates the year oforiginal adoption or,in the case of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.Asuperscript epsilon()indicates an editorial change since the last revision or reapproval.1.Scope1.1 This procedure details the determination of thiodiglycol(TDG),also known as 2,2-thiobis-ethanol,on wipes with3,3-thiodipropanol(TDP)as the surrogate.This method isbased upon solvent extraction of wipes by either sonication ora pressurized fluid extraction(PFE)technique as an alternativeoption.The extract is filtered,concentrated and analyzed byliquid chromatography/tandem mass spectrometry(LC/MS/MS).TDG is qualitatively and quantitatively determined.1.2 UnitsThe values stated in SI units are to be regardedas standard.No other units of measurement are included in thisstandard.1.3 The Method Detection Limit(MDL)2and ReportingRange3for TDG are listed in Table 1.1.4 This standard does not purport to address all of thesafety concerns,if any,associated with its use.It is theresponsibility of the user of this standard to establish appro-priate safety and health practices and determine the applica-bility of regulatory limitations prior to use.2.Referenced Documents2.1 ASTM Standards:4D653 Terminology Relating to Soil,Rock,and ContainedFluidsD1193 Specification for Reagent WaterD3694 Practices for Preparation of Sample Containers andfor Preservation of Organic ConstituentsD3740 Practice for Minimum Requirements for AgenciesEngaged in Testing and/or Inspection of Soil and Rock asUsed in Engineering Design and ConstructionE2554 Practice for Estimating and Monitoring the Uncer-tainty of Test Results of a Test Method in a SingleLaboratory Using a Control Sample Program2.2 Other Documents:EPA Publication SW-846 Test Methods for Evaluating SolidWaste,Physical/Chemical Methods5The Code of Federal Regulations,40 CFR Part 136,Appen-dix B3.Terminology3.1 Abbreviations:3.1.1 mMmillimolar,1 10-3moles/L3.1.2 NDnon-detect3.1.3 SRMsingle reaction monitoring3.1.4 MRMmultiple reaction monitoring3.1.5 VOAvolatile organic analysis4.Summary of Test Method4.1 For TDG wipe analysis,samples are shipped to the labbetween 0C and 6C.The samples are to be extracted,concentrated,and analyzed directly by LC/MS/MS within 7days of collection.The handling,storage,preservation,andLC/MS/MS analysis are consistent between the two extractionprocedures described in this test method.Only one extractionprocedure is required,documenting which was performed.4.2 TDG and TDP are identified by retention time and oneSRM transition.The target analyte and surrogate are quanti-tated using the SRM transitions utilizing an external calibra-tion.The final report issued for each sample lists the concen-tration of TDG and the TDP recovery.1This test method is under the jurisdiction of ASTM Committee E54 onHomeland Security Applications and is the direct responsibility of SubcommitteeE54.03 on Decontamination.Current edition approved Nov.1,2011.Published December 2011.DOI:10.1520/E2838-11.2The MDL is determined following the Code of Federal Regulations,40 CFRPart 136,Appendix B utilizing solvent extraction of wipes by sonication.3Reporting range concentrations are calculated from Table 4 concentrationsassuming a 10 Linjection of the lowest and highest level calibration standards witha 2 mL final extract volume.Volume variations will change the reporting limit andranges.The reporting limit(RL),lowest concentration of the reporting range,iscalculated from the concentration of the Level 1 calibration standard as shown inTable 4.4For referenced ASTM standards,visit the ASTM website,www.astm.org,orcontact ASTM Customer Service at serviceastm.org.For Annual Book of ASTMStandards volume information,refer to the standards Document Summary page onthe ASTM website.5Available from National Technical Information Service(NTIS),U.S.Depart-ment of Commerce,5285 Port Royal Road,Springfield,VA,22161 or at http:/www.epa.gov/epawaste/hazard/testmethods/index.htmCopyright ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959.United States1 5.Significance and Use5.1 This is a performance based method,and modificationsare allowed to improve performance.5.1.1 Due to the rapid development of newer instrumenta-tion and column chemistries changes to the analysis describedin this standard are allowed as long as better or equivalentperformance data result.Any modifications shall be docu-mented and performance data generated.The user of the datagenerated by this Standard shall be made aware of thesechanges and given the performance data demonstrating betteror equivalent performance.5.2 TDG is a Schedule 2 compound under the ChemicalWeapons Conv