ASTM_D_6378_-_07e1_rus.pdf

ASTM:D 6378-07e e1 (VPX),-()1 D 6378;,-.(e),.-e1 2007 .-1.*1.1 ,-.0(32F),7 150 (1.0 21 psi ()37.8(100F)4:1.,(1)(.6.1.1 3).1 ,0 100C 4:1 1:1(X=4 1)500(70 psi),(16).1.2 (VPX),4:1(X=4)-37.8C,(DVPE),D 5191(.16.2).1.3,(),.,.1.4 ,.,.7.2 7.8.-1 ASTM D02 D02.08 .1 2007.2007.1999.2006.D6378-06).2.,:D 323 ()D 2892 (15)D 4057 D 4177 D 4953 -()D 5191 (-)D 5842 D 5854 D 6299 D 6708 ,.3.3.1 ,:3.1.1 (DVPE)-,(D 5191),D4953,A.-2 ASTM,-ASTM,www.astm.org,ASTM serviceastm.org.ASTM Document Summary()ASTM.*.ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959,United States.1ASTM D 6378-07e e1 3.1.2 (PPA),-,.3.1.3 (RVPE)-,TPX,D 323.3.1.4 (TPX),-,X:1.3.1.5 (VPX),-PPA,X:1.VPX=TPX-PPA (1)3.2:3.2.1 DVPE-3.2.2 PPA 3.2.3 RVPE 3.2.4 TPX 3.2.5 VPX 4.4.1 20C .,.(X+1).TPX.PPA .(VPX)PPA TPX.2 ,PPA ,PPA .,PPA 7 (1 psi).5.5.1 .5.2 -.5.3 ,.5.4 ,.,-.VPX .5.5 ,.6.6.1,0 100C.1%,.,.6.1.1 ,5 15 ,4:1 1:1.-0.05.3-,5.5,(16).6.1.2 0 200 (0 29 psi)0.1 (0.01 psi)+0.2 (+0.03 psi).,.6.1.3 +0.1C .6.1.4 .0 100C,0.1C +0.1C.6.1.5 .6.2 ,0.01 (0.001 psi).6.3 0.01 0.67 (0.1 5 ).A6.3 D 2892 .6.4 ,0.1 (1 .),.3-,.,.2ASTM D 6378-07e e1 1 (ARV)*12)-ARV VP4(37.8oC)+,()()VP4(37.8oC)()-2,2 2,3 107.9+0.268.8+0.251.7+0.2+1.0+1.0+1.0107.9+1.2(106.7 109.1)68.8+1.2(67.6 70.0)51.7+1.2(50.5 52.9)-ARV VP4(37.8oC)+,(psi)(psi)VP4(37.8oC)(psi)-2,2 2,3 15.65+0.039.98+0.037.50+0.03+0.14+0.14+0.1415.65+0.17(15.48 15.82)9.98+0.17(9.81 10.15)7.50+0.17(7.33 7.67)-7.7.1 99%(.11).,3,.,.7.1.1 .7.3,7.4,7.7,(11),(),2003 (ILS)4(1 12).1 (ARV),.5 ,12 2003 ILS4 D 6378,():2,2-(11),2,3-(1).7.2,().7.32,2-,(2,2-).7.42,3-,(2,3-).7.5,(2,3-).7.6 2-,(2-).7.7,().7.8,().-3,DC.,BDH Ltd.,Poole,Dorset,UK.,U.S.PharmacopeialConvention,Inc.(USPC),Rockville,MD.4 -ASTMInternational RR:D02-1619.8.8.1.:8.1.1 .8.1.2 D4057,D 4177,D 5842 D 5854().,.250,1 1),70%80%.6 .6 ILS4,2003,250 1 (1).,D 4057,.,250 1,250 1.2 3,.1 2,VP4(37.8C),.16.2.3 250 1.,VP4(37.8C)64.3 (9.3 psi)1,250.-,VP4(37.8C)60.2 (8.7 psi)1,250.8.1.3 VPX()(.9.4),.VPX.,.8.1.4 .8.1.5 ,.3ASTM D 6378-07e e1VP4(37.8C)().1 VP4(37.8C)()VP4(37.8C)()8.2 ,.V/L(),5 (5).8.2.1 ,(,).-10 +50C 300 .58.2.2 ,250,1.,.8.2.3 ,-5 -ASTMInternational RR:D02-1609.,.8.2.4 ,.,2 (2 30 psia).8.2.5 .8.2.6 ,.,.,.4ASTM D 6378-07e e1VP4(37.8C)(psi).2 VP4(37.8C)(psi)VP4(37.8C)(psi)8.2.6.1 ,(.8.4),(,).,.8.2.6.2 ,.8.2.6.3 ,.8.3 -,70 80%,70%80%.,70%80%(8).8-,70%80%,70%80%.,.,.8.3.1 ,70%,.8.3.2 ,80%,70 80%.,.8.3.3 ,.8.4 -.,.,.().5ASTM D 6378-07e e1 ,.,.,16,(.15.2).9.9.1 .9.2 .,.9.3 ,.(.13.4).9.4 ,.,.10.10.1 :10.1.1 ,6,(11)(12).:(100,.,%50%.11.2,1,.,(),(10).12-,44.0/56.0(/)/,2003 ILS,4,.12.12.1 ,(QC),(),.12.2 VP4(37.8C).,.12.3 (QC),.X4 ,(QC).13 13.1 20 37.8C.6ASTM D 6378-07e e113.2 -X:1(,D 5191,-4:1).13.3 ,.,.13.4 (.9.3).13.5 .,-.13.6 .13.7 ,0.1 .TPX ,1.,20,0.3,TPX,1.13.8 ,TPX ,1.,20,0.3,TPX,2.13.9 13.8 ,TPX,3.13.10 ,(.8.4)14.14.1 ,PPAt,t,:TPX,1=,TPX,2=,TPX,3=,V1=,V2=,V3=.14.2 VPX,t t,:PPAt=t.14.3 X1 .15.14.1 0.1 (0.02 psi),(250 1),.2-,(r)250 1.10 (0.16 psi)1 0.015(X+B):X=VP4(37.8C)(psi),B=9 (1.31 psi).-:X=-,Pair=,Tm=.15.2 .8.4 ,.“xx.xH”“”.16.4,516.1 -2003 ,12,2 ,20 -.3.2 3.4 ,.16.1.1-,250 1,250,1,2,VP4(37.8C)17.0 106.0 (2.5 15.4 psi).16.1.2 -,250 1,250,1,3,VP4(37.8C)17.0 106.0(2.5 15.4 psi).16.1.3 4 1 2,VP4(37.8 C),(psi)2 3.16.2 D 5191 VP4(37.8C),1,DVPE D 5191,1,D 6708.,D 6708.,.6 DVPE,D 5191,1,7ASTM D 6378-07e e1 3-,(R)250 1.89 (0.27 psi)1 0.0273(X+B):X=VP4(37.8C)(psi),B=9 (1.31 psi).-VP4(37.8C),1.:VP4(37.8oC)1-L container=VP4(37.8oC),1,Relative Bias()=1.005 (0.15 psi)16.2.1 VP4(37.8C)250 DVPE D 5191 1 D 6708.,D 6708.,.7 DVPE,D 5191,1,VP4(37.8C),250.:VP4(37.8oC)250-mL container=VP4(37.8oC),250,Relative Bias()=0.751 (0.11 psi)16.2.2 ,2003,DVPE 6 7 ,DVPE,1 D 5191,5 6,.13 ,5 6.5 .,5.1 5.2 ,5 6.16.2.3 (250 1)-VP4(37.8C),250,1,D 6708.,8 9.D 6708.14 ,().8.4.15 D 5191 ,D 4953,B,D 323.VPX,:D 4953,EPA.EPA:DVPE=(0.956 Ptot)-2.39 DVPE=(0.956 Ptot)-0.347 psi =0.137 (0.02 psi)D 323,CARBCARB:RVPE=(0.972 Ptot)4.93 RVPE=(0.972 Ptot)0.715 psi =1.575 (0.23 psi)17.17.1 ;-;-;8ASTM D 6378-07e e1 4 VP4(37.8C),-250 1 250 1 VP4(38.7oC)()R()R()r()R()VP4(38.7oC)(psi)r(psi)R(psi)r(psi)R(psi)201.101.890.440.792.500.160.270.060.10251.101.890.510.933.000.160.270.060.12301.101.890.591.063.500.160.270.070.13351.101.890.661.204.000.160.270.080.14401.101.890.741.344.500.160.270.090.16451.101.890.811.475.000.160.270.090.17501.101.890.891.615.500.160.270.100.19551.101.890.961.756.000.160.270.110.20601.101.891.041.886.500.160.270.120.21651.101.891.112.027.000.160.270.120.23701.101.891.192.167.500.160.270.130.24751.101.891.262.298.000.160.270.140.25801.101.891.342.438.500.160.270.150.27851.101.891.412.579.000.160.270.150.28901.101.891.492.709.500.160.270.160.30951.101.891.562.8410.000.160.270.170.311001.101.891.642.9810.500.160.270.180.321051.101.891.713.1111.000.160.270.180.3411.500.160.270.190.3512.000.160.270.200.3612.500.160.270.210.3813.000.160.270.210.3913.500.160.270.220.4014.000.160.270.230.4214.500.160.270.240.4315.000.160.270.240.45-5 DVPE1-L Container 6 D 5191 DVPE9ASTM D 6378-07e e1 6 DVP