ASTM_D_8266_-_19.pdf

Designation:D826619Standard Test Method forAnalysis of Bisphenol A(4,4-Isopropylidenediphenol)byHigh Performance Liquid Chromatography1This standard is issued under the fixed designation D8266;the number immediately following the designation indicates the year oforiginal adoption or,in the case of revision,the year of last revision.A number in parentheses indicates the year of last reapproval.Asuperscript epsilon()indicates an editorial change since the last revision or reapproval.1.Scope1.1 This test method covers the determination of traceimpurities in bisphenol A(4,4-Isopropylidenediphenol)byreverse-phase gradient high performance liquid chromatogra-phy(HPLC).It is generally meant for the analysis of bisphenolA of 99.5%or greater.1.2 This method is applicable to bisphenol A samplescontaining impurity concentration between 2 and 400 mg/kg.Users of this method believe it is linear over a wider range.1.3 In determining the conformance of the test results usingthis method to applicable specification,results shall be roundedoff in accordance with the rounding-off method of PracticeE29.1.4 The values stated in SI units are to be regarded asstandard.No other units of measurement are included in thisstandard.1.5 This standard does not purport to address all of thesafety concerns,if any,associated with its use.It is theresponsibility of the user of this standard to establish appro-priate safety,health,and environmental practices and deter-mine the applicability of regulatory limitations prior to use.For a specific hazard statement,see Section 8.1.6 This international standard was developed in accor-dance with internationally recognized principles on standard-ization established in the Decision on Principles for theDevelopment of International Standards,Guides and Recom-mendations issued by the World Trade Organization TechnicalBarriers to Trade(TBT)Committee.2.Referenced Documents2.1 ASTM Standards:2D4297 Practice for Sampling and Handling BisphenolA(4,4-Isopropylidinediphenol)D6809 Guide for Quality Control and Quality AssuranceProcedures for Aromatic Hydrocarbons and Related Ma-terialsE29 Practice for Using Significant Digits in Test Data toDetermine Conformance with SpecificationsE691 Practice for Conducting an Interlaboratory Study toDetermine the Precision of a Test Method2.2 Other document:3OSHA Regulations 29 CFR paragraphs 1910.1000 and1910.12003.Summary of Test Method3.1 A known amount of an internal standard is added to asample of bisphenol A.The prepared sample is mixed andanalyzed by a reverse-phase gradient liquid chromatography(HPLC)equipped with an ultraviolet detector.The peak area ofeach impurity and the internal standard is measured.Theamount of each impurity is calculated from the ratio of the peakarea of the internal standard versus the peak area of theimpurity.4.Significance and Use4.1 Bisphenol A is used for production of polycarbonate orepoxy resin.The presence of impurities in bisphenol A isundesirable because they may slow down the polymerizationand be impurities in the final product.4.2 Determination of the trace impurities,such as isomer ofbisphenol A and the unreacted raw material,is often required.This test method is suitable for setting specifications and forusing as an internal quality control where these products areproduced or used.4.3 Purity is commonly reported by subtracting the deter-mined expected impurities and water from 100%.However,aHPLC analysis cannot determine absolute purity if unknowncomponents are contained within the material being examined.1This test method is under the jurisdiction of ASTM Committee D16 onAromatic,Industrial,Specialty and Related Chemicals and is the direct responsi-bility of Subcommittee D16.02 on Oxygenated Aromatics.Current edition approved June 1,2019.Published November 2019.DOI:10.1520/D8266-19.2For referenced ASTM standards,visit the ASTM website,www.astm.org,orcontact ASTM Customer Service at serviceastm.org.For Annual Book of ASTMStandards volume information,refer to the standards Document Summary page onthe ASTM website.3Available from U.S.Government Printing Office,Superintendent ofDocuments,732 N.Capitol St.,NW,Washington,DC 20401-0001,http:/www.access.gpo.gov.Copyright ASTM International,100 Barr Harbor Drive,PO Box C700,West Conshohocken,PA 19428-2959.United StatesThis international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for theDevelopment of International Standards,Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade(TBT)Committee.1 5.Interferences5.1 The internal standard chosen must be sufficiently re-solved from any impurity and the bisphenol A peak.5.2 Any solvent used must also be sufficiently resolved fromany impurity,the internal standard,and the bisphenol A peak.6.Apparatus6.1 High Performance Liquid Chromatograph(HPLC)Any HPLC capable of pumping the mobile phase at flow ratesbetween