Designation:D6978−05(Reapproved2013)StandardPracticeforAssessmentofResistanceofMedicalGlovestoPermeationbyChemotherapyDrugs1ThisstandardisissuedunderthefixeddesignationD6978;thenumberimmediatelyfollowingthedesignationindicatestheyearoforiginaladoptionor,inthecaseofrevision,theyearoflastrevision.Anumberinparenthesesindicatestheyearoflastreapproval.Asuperscriptepsilon(´)indicatesaneditorialchangesincethelastrevisionorreapproval.1.Scope1.1Thispracticecoversaprotocolfortheassessmentofresistanceofmedicalglovematerialstopermeationbypoten-tiallyhazardouscancerchemotherapydrugsunderconditionsofcontinuouscontact.Anassessmentismadebasedonthepermeation(breakthrough)ofninechemotherapydrugsthroughtheglovematerialoveracertainperiodoftime.1.2Itisemphasizedthattheconditionsusedinthisassess-mentareintendedtoapproximatetheworst-caseconditionforclinicaluses.Thedatashouldberestrictedtouseonarelativebasiswhencomparingglovematerials.1.3Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappro-priatesafetyandhealthpracticesanddeterminetheapplica-bilityofregulatorylimitationspriortouse.2.ReferencedDocuments2.1ASTMStandards:2D471TestMethodforRubberProperty—EffectofLiquidsD3577SpecificationforRubberSurgicalGlovesD3578SpecificationforRubberExaminationGlovesD3767PracticeforRubber—MeasurementofDimensionsD5250SpecificationforPoly(vinylchloride)GlovesforMedicalApplicationD6319SpecificationforNitrileExaminationGlovesforMedicalApplicationD6977SpecificationforPolychloropreneExaminationGlovesforMedicalApplicationF739TestMethodforPermeationofLiquidsandGasesthroughProtectiveClothingMaterialsunderConditionsofContinuousContact3.Terminology3.1Definitions:3.1.1SeeTestMethodF739,Section3onTerminologyforafulllistoftermsanddefinitions.3.1.2breakthroughdetectiontime,n—thetimeinminutesmeasuredfromthestartofthetesttothesamplingtimethatimmediatelyprecedesthesamplingtimeatwhichtheperme-ationratereaches0.01µg/cm2/min.Se...
