_API_TR_403-1995.pdf

API TR*40395m073229005547236T7AmericanPetroleumInstituteHealth and EnvironmentalSciences DepartmentClosed-Patch Repeated InsultDermal Sensitization Study ofTertiary Amyl Methyl Ether(TAME)in Guinea Pigs(Buehler Method)FEBRUARY 1995TOXICOLOGY REPORT NUMBER 403CAIS ABSTRACT NO.41-5416No reproduction or networking permitted without license from IHSNot for ResaleAPI TR*4039507322900554724533Strategies for TodayiOne of the most significant long-term trends affecting the future vitality of the petroleum industry is thepublics concerns about the environment.Recognizing this trend,API member companies have developed apositive,forward-looking strategy called STEP:Strategies for Todays Environmental Partnership.Thisprogram aims to address public concerns by improving our industrys environmental,health and safetyperformance;documenting performance improvements;and communicating them to the public.Thefoundation of STEP is the API Environmental Mission and Guiding Environmental Principles.API ENVIRONMENTAL MISSION AND GUIDING ENVIRONMENTAL PRINCIPLESThe members of the American Petroleum Institute are dedicated to continuous efforts to improve thecompatibility of our operations with the environment while economically developing energy resources andsupplying high quality products and services to consumers.The members recognize the importance ofefficiently meeting societys needs and our responsibility to work with the public,the govemment,and othersto develop and to use natural resources in an environmentally sound manner while protecting the health andsafety of our employees and the public.To meet these responsibilities,API members pledge to manage ourbusinesses according to these principles:To recognize and to respond to community concerns about our raw materials,products andoperations.To operate our plants and facilities,and to handle our raw materials and products in a manner thatprotects the environment,and the safety and health of our employees and the public.To make safety,health and environmental considerations a priority in our planning,and ourdevelopment of new products and processes.To advise promptly,appropriate officials,employees,customers and the public of information onsignificant industry-related safety,health and environmental hazards,and to recommendprotective measures.To counsel customers,transporters and others in the safe use,transportation and disposal of ourraw materials,products and waste materials.To economically develop and produce natural resources and to conserve those resources byusing energy efficiently.To extend knowledge by conducting or supporting research on the safety,health andenvironmental effects of our raw materials,products,processes and waste materials.To commit to reduce overall emission and waste generation.To work with others to resolve problems created by handling and disposal of hazardoussubstances from our operations.To participate with government and others in creating responsible laws,regulations and standardsto safeguard the community,workplace and environment.To promote these principles and practices by sharing experiences and offering assistance toothers who produce,handle,use,transport or dispose of similar raw materials,petroleum productsand wastes.Not for ResaleAPI TR*4039507322900554726306ACKNOWLEDGMENTSTHE FOLLOWING PEOPLE ARE RECOGNIZED FOR THEIR CONTRIBU-TIONS OF TIME AND EXPERTISE DURING THIS STUDY AND IN THEPREPARATION OF THIS REPORT:APLSTAFF CONTACTRichard Rhoden,Ph.D.,Health and Environmental Sciences DepartmentMEMBERS OF THE AIR/FUELS TOXICOLOGYHEALTH EFFECTS WORKGROUPRussell D.White,Ph.D.,Chairman,Chevron Research Technology,Inc.Rudolph J.Breglia,Ph.D.,BP America,Inc.Charles R.Clark,Ph.D.,UnocalWayne Daughtrey,Ph.D.,Exxon Biomedical Sciences,Inc.David Duncan,Texaco,Inc.Francis J.Koschier,Ph.D.,ARCOCharles A.Lapin,Ph.D.,ARCODavid C.Logan,M.D.,Mobil CorporationJohn H.Mitchell,M.D.,Amoco CorporationSusan A.Rodney,Ph.D.,Texaco,Inc.Ceinwen A.Schreiner,Ph.D.,Stonybrook LaboratoriesDavid R.Steup,Ph.D.,Shell Oil CompanyMichael S.Wells,Ph.D.,Amoco Corporation”44444.4No reproducion or networking permitled without censerom HSNot for Resale