波依定与代文合用于原发性高血压患者的疗效观察温州医学院附属第二医院药剂科（325027）张友婷戈霓云温州医学院附属第二医院内科吴成云【摘要】目的探讨波依定（化学成分：非洛地平）与代文（化学成分：缬沙坦）合用的降压疗效及不良反应。方法门诊选取60例中、重度原发性高血压患者，随机分为两组。非洛地平组30例，口服非洛地平5㎎/d或10mg/d，疗程8周；非洛地平与缬沙坦合用组30例，口服非洛地平5㎎/d，加缬沙坦80㎎/d，疗程8周，监测其血压及各项相关指标。结果非洛地平合用缬沙坦组降压有效率明显优于非洛地平组，无明显不良反应。结论非洛地平与缬沙坦联合应用于中、重度原发性高血压效果比单用非洛地平组更有效。【关键词】非洛地平：缬沙坦：高血压AeffectsurveyontherapyofprimaryhypertensionbyPlendilcombinewithDiovan.ZhangYou-ting，GeNi-yun,Departmentofpharmacy,thesecondaffiliatedhospitalofWenZhouMedicalCollege.WuChen-yunDepartmentofmedicine,thesecondaffiliatedhospitalofWenZhouMedicalCollege【Abstract】ObjectiveToresearchtheantihypertensiveeffectandadversereactionbyPlendil(chemicalcomponent:felodipine)combinewithDiovan(chemicalcomponentvalsartan).Method60moderateorseverehypertensivepatientsweredividedintotwogroupswhichisgroupfelodipineandgroupcombination(felodipineandvalsartan)randomly,eachofthemhas30cases.Groupfelodipineweretake5milligrameor10milligramefelodipineperdayorallyfor8weeksandgroupcombinationweretake5milligramefelodipineand80milligramevalsartanperdayorallyfor8weeks,thentomeasurethebloodpressure,heartrateandsomebiochemistryindex.ResultsCompairedwithgroupfelodipine,theantihypertensioneffectwasbetteringroupcombination,andtheadversereactionwasfew.ConclusionIt`smoreeffectualthatthecombinativeusebyfelodipineandvalsartantotreatmoderateorseverehypertensionthansingleusebyfelodipine.【keywords】felodipine:valsartan:hypertensive高血压是以体循环动脉压增高为主要表现的临床综合征，是最常见的心血管疾病[1.2]机体血压升高是多种病理生理机制参与的，使用一种降压药往往效果不理想。目前倾向于主张不同降压机制的药物联合使用，以获得满意的效果。本文旨在研究二氢吡啶类钙通道阻滞剂非洛地平与血管紧张素Ⅱ受体拮抗剂缬沙坦合用的降压...
